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June 2024

· 3 min read

This software release includes:

  • Updates to the eProtein Discovery Software (4.6.0)
  • Updates to the eProtein Discovery Cloud Software
  • Updates to the eProtein Discovery Screen Experiment (4.0.1)

eProtein Discovery (cloud) software​

Improvements to protein entry​

  • DNA synthesis compatibility checks are more robust

“Results” and “Scale-up Data” tabs​

Several improvements to the “Results” and “Scale-up Data” tabs, which will be available for experiments created using the workflow “eProtein Discovery Screen Experiment 4.0.0”

  • In the Expression Yield Result table in the Results tab, expression conditions that were selected for purification are indicated with a blue tick
  • eGene recipes that include the 3C protease additive are now annotated with a scissor icon in measurement tables
  • The Scale-up Data tab now features an interactive graph which allows users to visualize predicted yields of constructs which were screened and purified.
  • Constructs and conditions for scale up can be added to the Scale-up table by selecting from the graph. Scale-up volume and predicted yield can be adjusted to meet desired yield. The data from this table generates a downloadable .csv with calculated volumes to facilitate scale up set up at the bench.

Bug fixes​

  • The “Possible constructs” tab is only visible after a protein is finalized
  • The “Archive” button is re-positioned for improved visibility
  • Any runs which were created with a protein that was later archived will have a warning when they get finalized

Instrument Software Release​

Version 4.6.0​

  • AI/ML-based automated droplet quality checks enabled. This feature will improve droplet quality checks and flag any compromised reactions to the user

Process improvements​

  • PDF generation and report now downloadable straight from the instrument
  • USB Export function now enabled
  • Increased system memory stability

Bug fixes​

  • Automated Workflow version checks to ensure compatibility
  • Optimized CPU usage
  • Fixed issue occasionally observed due to rapid back to back runs
  • eProtein Discovery Instrument software / Firmware interface with improved logging

Offline instrument (only for instruments installed to run in offline mode):​

  • Generic run can be created on the instrument without connection to the cloud software
  • Constructs and cell-free blend will be differentiated with a standard naming convention and cannot be customized on screen
  • Generic downselection of 30 highest expressing construct to the purification round
  • USB only data export functionality enabled

New Workflow Releases

eProtein Discovery Screen Experiment 4.0.0​

⚠ The workflow version will only be available once the instrument software has been updated to version 4.6.0. The following features will not be available retrospectively.

  • Warnings are now displayed for measurements that may have been affected by droplet operation issues
  • A Transfer Plate Guide can now be downloaded from the experiment's Progress tab

eProtein Discovery Screen Experiment 4.0.1​

eProtein Discovery Screen Experiment 4.0.1 now replaces eProtein Discovery Screen Experiment 4.0.0 with the following updates:

  • Fixed an issue where the "Top combinations for purified yield" table showed incorrect values